How Is Serum Sickness Diagnosed?

What are the 4 types of hypersensitivity?

Type I: Immediate Hypersensitivity (Anaphylactic Reaction) These allergic reactions are systemic or localized, as in allergic dermatitis (e.g., hives, wheal and erythema reactions).

Type II: Cytotoxic Reaction (Antibody-dependent) …

Type III: Immune Complex Reaction.

Type IV: Cell-Mediated (Delayed Hypersensitivity).

What is the cause of a delayed allergic reaction?

One type of immune reaction is due to production of antibodies called Immunoglobulin E (IgE) specific to the drug. … These T cells orchestrate a delayed immune response that most often affects the skin, causing itchy rashes, and occurs days to weeks after exposure to the drug.

What type of hypersensitivity reaction is serum sickness?

Serum sickness is a type III hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum.

Is serum sickness an autoimmune disease?

Serum sickness is an immune complex–mediated hypersensitivity reaction characterized by fever, rash, arthritis, arthralgia, and other systemic symptoms. … With regard to patient education on serum sickness, the patient and his or her family should be advised of the nature of the offending agent.

Can you get serum sickness from a bee sting?

Delayed Reaction to an Insect Sting Reactions occurring more than four hours after a bee or other insect sting are classified as delayed reactions. There have been isolated reports of serum sickness-like syndromes occurring about a week after a sting.

What is serum sickness syndrome?

Serum sickness is a type III hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum. … Historically, the term serum sickness connotes a self-limited syndrome caused by deposition of immune complexes resulting from exposure to foreign proteins or haptens.

How do you treat serum sickness?

Treatment for serum sickness is aimed at reducing symptoms. Your doctor may prescribe antihistamines or analgesics (NSAIDs), along with topical medications to relieve itching or rash. In serious cases, your doctor may prescribe corticosteroids, such as prednisone. Normally, there is no need for hospitalization.

What is an example of delayed hypersensitivity?

Examples of DTH reactions are contact dermatitis (eg, poison ivy rash), tuberculin skin test reactions, granulomatous inflammation (eg, sarcoidosis, Crohn disease), allograft rejection, graft versus host disease, and autoimmune hypersensitivity reactions.

How long does serum sickness reaction last?

Serum sickness usually improves in 7 to 10 days, with full recovery in 2 to 4 weeks. However, it may lead to nervous system disorders and a life-threatening allergic reaction called anaphylaxis, so it is important to get medical treatment.

How do you test for serum sickness?

The following studies are indicated in patients with serum sickness:CBC with differential – Leukocytosis or leukopenia, eosinophilia, or mild thrombocytopenia.Erythrocyte sedimentation rate and C-reactive protein levels – Usually slightly elevated.Urinalysis – Proteinuria, hematuria, active sediment.More items…•

Will serum sickness go away on its own?

While it can cause serious symptoms, serum sickness typically goes away on its own within a week to six weeks. … They can help to confirm if you have serum sickness and get you started on medication to help manage your symptoms.

What medications cause serum sickness?

Some of the drugs associated with serum sickness are:allopurinol.barbiturates.captopril.cephalosporins.crofab.griseofulvin.penicillins.phenytoin.More items…

How do you prevent serum sickness?

There is no known way to prevent the development of serum sickness. People who have had serum sickness or drug allergy should avoid future use of the antiserum or drug.

What are the symptoms of serum sickness?

Symptoms of serum sickness can include:Fever.General ill feeling.Hives.Itching.Joint pain.Rash.Swollen lymph nodes.

Is serum sickness serious?

Serum sickness usually improves in 7 to 10 days, with full recovery in 2 to 4 weeks. However, it may lead to nervous system disorders and a life-threatening allergic reaction called anaphylaxis, so it is important to get medical treatment.